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Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells.
- Source :
-
Mucosal immunology [Mucosal Immunol] 2015 Jan; Vol. 8 (1), pp. 141-51. Date of Electronic Publication: 2014 Jun 18. - Publication Year :
- 2015
-
Abstract
- Mucosal dendritic cells (DCs) in the intestine acquire the unique capacity to produce retinoic acid (RA), a vitamin A metabolite that induces gut tropism and regulates the functional differentiation of the T cells they prime. Here, we identified a stromal cell (SC) population in the intestinal lamina propria (LP), which is capable of inducing RA production in DCs in a RA- and granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent fashion. Unlike DCs, LP SCs constitutively expressed the enzymatic machinery to produce RA even in the absence of dietary vitamin A, but were not able to do so in germ-free mice implying regulation by microbiota. Interestingly, DCs promoted GM-CSF production by the SCs indicating a two-way cross-talk between both cell types. Furthermore, RA-producing LP SCs and intestinal DCs localized closely in vivo suggesting that the interactions between both cell types might have an important role in the functional education of migratory DCs and therefore in the regulation of immune responses toward oral and commensal antigens.
- Subjects :
- Animals
Cell Communication
Cell Differentiation
Cell Movement
Cells, Cultured
Diet
Granulocyte-Macrophage Colony-Stimulating Factor metabolism
Immunity, Mucosal
Immunomodulation
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Mice, Knockout
Tretinoin immunology
Dendritic Cells immunology
Mucous Membrane immunology
Stromal Cells immunology
T-Lymphocytes immunology
Tretinoin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1935-3456
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Mucosal immunology
- Publication Type :
- Academic Journal
- Accession number :
- 24938743
- Full Text :
- https://doi.org/10.1038/mi.2014.51