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An inflammatory myofibroblastic tumor exhibiting immunoreactivity to KIT: a case report focusing on a diagnostic pitfall.
- Source :
-
World journal of surgical oncology [World J Surg Oncol] 2014 Jun 18; Vol. 12, pp. 186. Date of Electronic Publication: 2014 Jun 18. - Publication Year :
- 2014
-
Abstract
- Inflammatory myofibroblastic tumors (IMTs) and gastrointestinal stromal tumors (GISTs) are both spindle cell tumors, and occur rarely in the wall of the urinary bladder. In general, immunostaining allows differentiation of IMTs and GISTs. Most IMTs are positive for anaplastic lymphoma kinase (ALK) and negative for KIT, whereas most GISTs are ALK-negative and KIT-positive. Here, we describe a case of a spindle cell tumor in the wall of the urinary bladder. The spindle cells were positive for both ALK and KIT, and it was thus difficult to determine whether the tumor was an IMT or a GIST. We eventually diagnosed an IMT, because ALK gene rearrangement was confirmed by fluorescent in-situ hybridization. Cytoplasmic staining for KIT and the absence of other GIST markers, including DOG1 and platelet-derived growth factor α, indicated that the tumor was not a GIST. Therefore, IMTs should be included in the differential diagnosis of spindle cell tumors, even those that are KIT-positive.
- Subjects :
- Adult
Anaplastic Lymphoma Kinase
Biomarkers, Tumor genetics
Diagnosis, Differential
Female
Gastrointestinal Stromal Tumors metabolism
Gastrointestinal Stromal Tumors surgery
Humans
Immunoenzyme Techniques
In Situ Hybridization, Fluorescence
Inflammation metabolism
Inflammation surgery
Myofibroma metabolism
Myofibroma surgery
Prognosis
Receptor Protein-Tyrosine Kinases genetics
Urinary Bladder Neoplasms metabolism
Urinary Bladder Neoplasms surgery
Biomarkers, Tumor metabolism
Diagnostic Errors prevention & control
Gastrointestinal Stromal Tumors diagnosis
Inflammation diagnosis
Myofibroma diagnosis
Proto-Oncogene Proteins c-kit metabolism
Urinary Bladder Neoplasms diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1477-7819
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- World journal of surgical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 24938355
- Full Text :
- https://doi.org/10.1186/1477-7819-12-186