Back to Search
Start Over
Decreased HIV type 1 transcription in CCR5-Δ32 heterozygotes during suppressive antiretroviral therapy.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2014 Dec 01; Vol. 210 (11), pp. 1838-43. Date of Electronic Publication: 2014 Jun 16. - Publication Year :
- 2014
-
Abstract
- Individuals who are heterozygous for the CCR5-Δ32 mutation provide a natural model to examine the effects of reduced CCR5 expression on human immunodeficiency virus (HIV) persistence. We evaluated the HIV reservoir in 18 CCR5-Δ32 heterozygotes and 54 CCR5 wild-type individuals during suppressive antiretroviral therapy. Cell-associated HIV RNA levels (P=.035), RNA to DNA transcriptional ratios (P=.013), and frequency of detectable HIV 2-long terminal repeat circular DNA (P=.013) were significantly lower in CD4+ T cells from CCR5-Δ32 heterozygotes. Cell-associated HIV RNA was significantly correlated with CCR5 surface expression on CD4+ T cells (r2=0.136; P=.002). Our findings suggest that curative strategies should further explore manipulation of CCR5.<br /> (© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes immunology
CD4-Positive T-Lymphocytes metabolism
CD8-Positive T-Lymphocytes immunology
CD8-Positive T-Lymphocytes metabolism
Cohort Studies
Genotype
HIV Infections drug therapy
HIV Infections immunology
HIV-1 immunology
Humans
Phenotype
RNA, Viral genetics
Viral Load
Gene Expression Regulation, Viral
HIV Infections genetics
HIV Infections virology
HIV-1 genetics
Heterozygote
Mutation
Receptors, CCR5 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 210
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 24935955
- Full Text :
- https://doi.org/10.1093/infdis/jiu338