Burn after feeding. An old uncoupler of oxidative phosphorylation is redesigned for the treatment of nonalcoholic fatty liver disease.

Authors :: Fromenty B
Source :: Clinics and research in hepatology and gastroenterology [Clin Res Hepatol Gastroenterol] 2014 Oct; Vol. 38 (5), pp. 545-9. Date of Electronic Publication: 2014 Jun 09.
Publication Year :: 2014
Abstract: Uncoupling of oxidative phosphorylation (OXPHOS) in brown adipose tissue can be used by hibernating animals to produce heat at the expense of their fat mass. In a recent work, Dr Shulman et al. generated a liver-targeted derivative of the prototypical OXPHOS uncoupler 2,4-dinitrophenol that alleviated steatosis, hypertriglyceridemia and insulin resistance in several models of nonalcoholic fatty liver disease and type 2 diabetes.<br /> (Copyright © 2014 Elsevier Masson SAS. All rights reserved.)

Subjects :: Animals
Mice
Rats
2,4-Dinitrophenol therapeutic use
Non-alcoholic Fatty Liver Disease drug therapy
Non-alcoholic Fatty Liver Disease metabolism
Oxidative Phosphorylation
Uncoupling Agents therapeutic use

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