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Comparative study of NMP-preloaded and dip-loaded membranes for guided bone regeneration of rabbit cranial defects.
Comparative study of NMP-preloaded and dip-loaded membranes for guided bone regeneration of rabbit cranial defects.
- Source :
-
Journal of tissue engineering and regenerative medicine [J Tissue Eng Regen Med] 2017 Feb; Vol. 11 (2), pp. 425-433. Date of Electronic Publication: 2014 Jun 12. - Publication Year :
- 2017
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Abstract
- Guided bone regeneration (GBR) has been utilized for several decades for the healing of cranio-maxillofacial bone defects and, particularly in the dental field, by creating space with a barrier membrane to exclude soft tissue and encourage bone growth in the membrane-protected volume. Although the first membranes were non-resorbable, a new generation of GBR membranes aims to biodegrade and provide bioactivity for better overall results. The Inion GTRâ„¢ poly(lactide-co-glycolide) (PLGA) membrane is not only resorbable but also bioactive, since it includes N-methylpyrrolidone (NMP), which has been shown to promote bone regeneration. In this study, the effects of loading different amounts of NMP onto the membrane through chemical vapour deposition or dipping have been explored. In vitro release demonstrated that lower levels of NMP led to lower NMP concentrations and slower release, based on total NMP loaded in the membrane. The dipped membrane released almost all of the NMP within 15 min, leading to a high NMP concentration. For the in vivo studies in rabbits, 6 mm calvarial defects were created and left untreated or covered with an ePTFE membrane or PLGA membranes dipped in, or preloaded with, NMP. Evaluation of the bony regeneration revealed that the barrier membranes improved bony healing and that a decrease in NMP content improved the performance. Overall, we have demonstrated the potential of these PLGA membranes with a more favourable NMP release profile and the significance of exploring the effect of NMP on these PLGA membranes with regard to bone ingrowth. Copyright © 2014 John Wiley & Sons, Ltd.<br /> (Copyright © 2014 John Wiley & Sons, Ltd.)
- Subjects :
- Animals
Biocompatible Materials chemistry
Bone Substitutes chemistry
Membranes, Artificial
Microscopy, Electron, Scanning
Polylactic Acid-Polyglycolic Acid Copolymer
Rabbits
Absorbable Implants
Bone Regeneration drug effects
Guided Tissue Regeneration methods
Lactic Acid chemistry
Polyglycolic Acid chemistry
Pyrrolidinones chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1932-7005
- Volume :
- 11
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of tissue engineering and regenerative medicine
- Publication Type :
- Academic Journal
- Accession number :
- 24919954
- Full Text :
- https://doi.org/10.1002/term.1926