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Cross-reactive influenza-specific antibody-dependent cellular cytotoxicity in intravenous immunoglobulin as a potential therapeutic against emerging influenza viruses.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2014 Dec 01; Vol. 210 (11), pp. 1811-22. Date of Electronic Publication: 2014 Jun 10. - Publication Year :
- 2014
-
Abstract
- Background: Intravenous immunoglobulin (IVIG) is a purified pool of human antibodies from thousands of donors that is used to prevent or treat primary immune deficiency, several infectious diseases, and autoimmune diseases. The antibodies that mediate antibody-dependent cellular cytotoxicity (ADCC) against heterologous influenza strains may be present in IVIG preparations.<br />Methods: We tested 8 IVIG preparations prior to the 2009 H1N1 swine-origin influenza pandemic and 10 IVIG preparations made after 2010 for their ability to mediate influenza-specific ADCC.<br />Results: ADCC mediating antibodies to A(H1N1)pdm09 hemagglutinin (HA) and neuraminidase (NA) were detected in IVIG preparations prior to the 2009-H1N1 pandemic. The HA-specific ADCC targeted both the HA1 and HA2 regions of A(H1N1)pdm09 HA and was capable of recognizing a broad range of HA proteins including those from recent avian influenza strains A(H5N1) and A(H7N9). The low but detectable ADCC recognition of A(H7N9) was likely due to rare individuals in the population contributing cross-reactive antibodies to IVIG.<br />Conclusions: IVIG preparations contain broadly cross-reactive ADCC mediating antibodies. IVIG may provide at least some level of protection for individuals at high risk of severe influenza disease, especially during influenza pandemics prior to the development of effective vaccines.<br /> (© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Antibodies, Viral blood
Female
Hemagglutination Tests
Hemagglutinin Glycoproteins, Influenza Virus immunology
Humans
Influenza A Virus, H7N9 Subtype immunology
Killer Cells, Natural immunology
Male
Middle Aged
Young Adult
Antibodies, Viral immunology
Antibody-Dependent Cell Cytotoxicity immunology
Cross Reactions immunology
Immunoglobulins, Intravenous therapeutic use
Influenza A Virus, H1N1 Subtype immunology
Influenza, Human immunology
Influenza, Human therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 210
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 24916185
- Full Text :
- https://doi.org/10.1093/infdis/jiu334