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D-galactose induced inflammation lipid peroxidation and platelet activation in rats.
- Source :
-
Cytokine [Cytokine] 2014 Sep; Vol. 69 (1), pp. 150-3. Date of Electronic Publication: 2014 Jun 06. - Publication Year :
- 2014
-
Abstract
- Background: To investigate events possibly related to the development of D-galactose induced senescence, we examined whether 8-iso PGF(2α) formation, a marker of in vivo lipid peroxidation is altered and whether its biosynthesis is associated with 11-dehydro-TXB(2) excretion rate, as a marker of in vivo platelet activation. In this setting, we also investigated the relationship between proinflammatory mediators (IL-6 and TNF-α from one, and lipid peroxidation and platelet activation, from another aspect.<br />Methods and Results: Forty animals were divided, depending on treatment with d-galactose into: placebo and D-galactose treated rats. 8-iso-PGF(2α), IL-6 and TNF-α were measured in plasma, while 11-dehydro-TXB(2) was determined in the urine after a six week treatment with d-galactose. Compared to placebo, d-galactose treated animals showed significantly higher levels of all measured parameters.<br />Conclusions: D-galactose induced changes in the rate of F(2)-isoprostane formation are associated with the changes in the excretion rate of 11-dehydro-TXB(2).<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Arachidonic Acid metabolism
Cellular Senescence
Dinoprost biosynthesis
Dinoprost blood
Inflammation chemically induced
Interleukin-6 blood
Male
Rats
Rats, Wistar
Thromboxane B2 metabolism
Thromboxane B2 urine
Tumor Necrosis Factor-alpha blood
Dinoprost analogs & derivatives
Galactose pharmacology
Lipid Peroxidation drug effects
Platelet Activation immunology
Thromboxane B2 analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0023
- Volume :
- 69
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cytokine
- Publication Type :
- Academic Journal
- Accession number :
- 24907931
- Full Text :
- https://doi.org/10.1016/j.cyto.2014.05.006