Back to Search
Start Over
Lipodiscamides A-C, new cytotoxic lipopeptides from Discodermia kiiensis.
- Source :
-
Organic letters [Org Lett] 2014 Jun 20; Vol. 16 (12), pp. 3256-9. Date of Electronic Publication: 2014 Jun 06. - Publication Year :
- 2014
-
Abstract
- Lipodiscamides A-C, three new lipodepsipeptides, were characterized from the marine sponge Discodermia kiiensis. These structurally rare cyclic lipodepsipeptides were found to possess an unprecedented dilactone macrocycle and, thus, represent a new family of lipopeptides. They are the only lipopeptides bearing 4S-hydroxy-trans-2-enoate, and noncanonical amino acids, l-3-ureidoalanine (Uda), E-dehydronorvaline (Denor), and d-citrulline (Cit). MTT assays against P388 and HeLa cells revealed the moderate cytotoxicity of all three compounds.
- Subjects :
- Amino Acids chemistry
Animals
Anti-Bacterial Agents chemistry
Antineoplastic Agents chemistry
Bacillus cereus drug effects
Candida albicans drug effects
Citrulline chemistry
Drug Screening Assays, Antitumor
Escherichia coli drug effects
HeLa Cells
Humans
Leukemia P388
Lipopeptides chemistry
Marine Biology
Methicillin-Resistant Staphylococcus aureus drug effects
Microbial Sensitivity Tests
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Stereoisomerism
Anti-Bacterial Agents isolation & purification
Anti-Bacterial Agents pharmacology
Antineoplastic Agents isolation & purification
Antineoplastic Agents pharmacology
Lipopeptides isolation & purification
Lipopeptides pharmacology
Porifera chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 16
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 24906171
- Full Text :
- https://doi.org/10.1021/ol501271v