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Image-guided radiation therapy based on helical tomotherapy in prostate cancer: minimizing toxicity.
- Source :
-
Oncology research and treatment [Oncol Res Treat] 2014; Vol. 37 (6), pp. 324-30. Date of Electronic Publication: 2014 May 12. - Publication Year :
- 2014
-
Abstract
- Background: We report the clinical results and prognostic factors of image-guided radiation therapy (RT) with helical tomotherapy (HT) for localized and recurrent prostate cancer (PC).<br />Patients and Methods: We evaluated 70 patients with PC (primary diagnosis, n = 48; adjuvant, n = 5; salvage, n = 17) treated with HT from May 2006 through January 2011. The dose prescribed to the prostate/surgical bed ranged between 60 and 78 Gy. Potential risk factors for genitourinary (GU) and gastrointestinal (GI) toxicity were assessed.<br />Results: The median age was 68 years (range 51-87 years). The median follow-up was 37 months (range 3-74 months). The rates of acute grade 2 GI and GU toxicities were 10 and 13%, respectively. Only 1 patient experienced acute grade 3 GU toxicity. The rates of late grade ≥ 2 GI and GU toxicities were 1% each. Multivariate analysis showed an association between rectum mean dose > median (39 Gy) and bladder median dose > median (46 Gy) with a higher grade of acute GI (p = 0.017) and GU (p = 0.019) toxicity, respectively. Additionally, older age was associated with late GU toxicity (p = 0.026).<br />Conclusion: Toxicity with HT is low and is associated with higher median/mean doses in organs at risk as well as with older age. A prospective validation would be necessary to confirm these results.<br /> (© 2014 S. Karger GmbH, Freiburg.)
- Subjects :
- Aged
Aged, 80 and over
Gastrointestinal Diseases prevention & control
Humans
Male
Male Urogenital Diseases prevention & control
Middle Aged
Prostatic Neoplasms diagnostic imaging
Radiation Injuries prevention & control
Radiation Protection methods
Radiotherapy Dosage
Radiotherapy, Image-Guided adverse effects
Retrospective Studies
Tomography, Spiral Computed methods
Treatment Outcome
Gastrointestinal Diseases etiology
Male Urogenital Diseases etiology
Prostatic Neoplasms radiotherapy
Radiation Injuries etiology
Radiotherapy, Image-Guided methods
Radiotherapy, Intensity-Modulated adverse effects
Radiotherapy, Intensity-Modulated methods
Subjects
Details
- Language :
- English
- ISSN :
- 2296-5262
- Volume :
- 37
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Oncology research and treatment
- Publication Type :
- Academic Journal
- Accession number :
- 24903763
- Full Text :
- https://doi.org/10.1159/000362858