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Hypoglycemic and hypolipidemic activities of Arabic and Indian origin Salvadora persica root extract on diabetic rats with histopathology of their pancreas.
- Source :
-
International journal of health sciences [Int J Health Sci (Qassim)] 2014 Jan; Vol. 8 (1), pp. 45-56. - Publication Year :
- 2014
-
Abstract
- Objective: To evaluate hypoglycemic and hypolipidemic effects of Salvadora persica aqueous extracts on streptozotocin-induced diabetic rats by measuring fasting blood glucose levels, lipid profiles and histopathological analysis of pancreas.<br />Materials and Methods: Experimental Diabetes was induced by single intraperitoneal injection of streptozotocin (60 mg/kg) to albino Wistar rats. Salvadora persica extracts were administered orally at 250 and 500 mg/kg dose levels for 21 days. Glucose tolerance test (GTT) was performed on 16 h fasted rats and changes in blood glucose levels, total cholesterol, triglycerides, low-density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL) and histopathology of pancreas were performed.<br />Results: At a dose level of 500 mg/kg, blood glucose 85.25 ± 13.20 mg/dl, total cholesterol (TC) 114.57 ± 15.81(mg/dl), triglycerides (TG) 75.40 ± 16.47(mg/dl), LDL 42.63 ± 13.17(mg/dl), VLDL 22.78 ± 1.88(mg/dl), and elevation of HDL 44.88 ± 11.61(mg/dl) were found in comparison with diabetic control on 28(th) day by Arabic origin Salvadora persica. It also accelerated the regeneration of β-cells in experimental animal's pancreas to 32.6 ± 2.4 compared to diabetic control animal's pancreas of 8.1 ± 0.5 at the end of 28(th) day.<br />Conclusion: This study confirmed that Arabic Salvadora persica aqueous extracts at 500 mg/kg dose level, in comparison to other extracts (Indian Salvadora persica, 250 and 500 mg/kg, Arabic Salvadora persica 250 mg/kg) possessed significant hypoglycemic and hypolipidemic activities and regenerated pancreatic β-cells in streptozotocin treated diabetic rats.
Details
- Language :
- English
- ISSN :
- 1658-3639
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of health sciences
- Publication Type :
- Academic Journal
- Accession number :
- 24899879
- Full Text :
- https://doi.org/10.12816/0006071