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Photobiological characteristics of chlorophyll a derivatives as microbial PDT agents.
- Source :
-
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology [Photochem Photobiol Sci] 2014 Aug; Vol. 13 (8), pp. 1137-45. - Publication Year :
- 2014
-
Abstract
- Chlorin-e6 (chl-e6) and a hydrogenated derivative (chl-e6H) were semi-synthesized, and their photophysical properties and photodynamic activity against Escherichia coli, Staphylococcus aureus and Candida albicans evaluated. Methyl pheophorbide-a (Mepheo-a) was obtained from S. maxima using methanolic extraction with acid catalysis (CH3OH–H2SO4). Chlorin-e6 was prepared from Mepheo-a by basic hydrolysis with H2O–acetone and NaOH. Hydrogenated Chlorin-e6 was synthesized by a similar procedure starting from the hydrogenated methyl pheophorbide-a (Mepheo-aH). Photophysical studies were performed in order to determine the singlet oxygen quantum yield of chl-e6H which is higher than that of chl-e6. The microorganism inactivation of chl-e6 and chl-e6H was investigated at two concentrations and three fluence levels. Both chl-e6 and chl-e6H showed microorganism inactivation against Gram-positive bacteria and a fungus.
- Subjects :
- Anti-Infective Agents chemistry
Anti-Infective Agents radiation effects
Candida albicans drug effects
Chlorophyll chemistry
Chlorophyll radiation effects
Chlorophyll A
Chlorophyllides
Escherichia coli drug effects
Hydrogenation
Molecular Structure
Photobleaching
Photochemical Processes
Photosensitizing Agents chemistry
Photosensitizing Agents pharmacology
Photosensitizing Agents radiation effects
Porphyrins chemistry
Porphyrins pharmacology
Porphyrins radiation effects
Staphylococcus aureus drug effects
Anti-Infective Agents pharmacology
Chlorophyll pharmacology
Photochemotherapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1474-9092
- Volume :
- 13
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
- Publication Type :
- Academic Journal
- Accession number :
- 24898703
- Full Text :
- https://doi.org/10.1039/c3pp50376c