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Epstein-Barr virus, the germinal centre and the development of Hodgkin's lymphoma.
- Source :
-
The Journal of general virology [J Gen Virol] 2014 Sep; Vol. 95 (Pt 9), pp. 1861-1869. Date of Electronic Publication: 2014 Jun 03. - Publication Year :
- 2014
-
Abstract
- The relationship between Epstein-Barr virus (EBV) and the germinal centre (GC) of the asymptomatic host remains an enigma. The occasional appearance of EBV-positive germinal centres in some patients, particularly those with a history of immunosuppression, suggests that EBV numbers in the GC are subject to immune control. The relationship, if any, between lymphoid hyperplasia with EBV-positive germinal centres and subsequent or concurrent lymphomagenesis remains to be clarified. As far as the development of EBV-associated Hodgkin's lymphoma is concerned, the suppression of virus replication, mediated by LMP1 on the one hand, and the loss of B-cell receptor signalling on the other, appears to be an important pathogenic mechanism. A further important emerging concept is that alterations in the microenvironment of the EBV-infected B-cell may be important for lymphomagenesis.<br /> (© 2014 The Authors.)
- Subjects :
- Adult
B-Lymphocytes immunology
Cell Differentiation immunology
Epstein-Barr Virus Infections virology
Female
Hodgkin Disease immunology
Humans
Male
Middle Aged
Pseudolymphoma virology
Receptors, Antigen, B-Cell immunology
Viral Matrix Proteins
Virus Replication immunology
Young Adult
B-Lymphocytes virology
Germinal Center immunology
Germinal Center virology
Herpesvirus 4, Human immunology
Hodgkin Disease virology
Subjects
Details
- Language :
- English
- ISSN :
- 1465-2099
- Volume :
- 95
- Issue :
- Pt 9
- Database :
- MEDLINE
- Journal :
- The Journal of general virology
- Publication Type :
- Academic Journal
- Accession number :
- 24893782
- Full Text :
- https://doi.org/10.1099/vir.0.066712-0