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Cell cycle disruption and apoptosis as mechanisms of toxicity of organochlorines in Zea mays roots.
- Source :
-
Journal of hazardous materials [J Hazard Mater] 2014 Jul 15; Vol. 276, pp. 312-22. Date of Electronic Publication: 2014 May 23. - Publication Year :
- 2014
-
Abstract
- Organochlorine pesticides (OCPs) are widespread environmental pollutants; two of them are highly persistent: lindane (γHCH) and chlordecone (CLD). Maize plants cope with high levels of OCP-environmental pollution, however little is known about cellular mechanisms involved in plant response to such OCP-exposures. This research was aimed at understanding the physiological pathways involved in the plant response to OCPs in function of a gradient of exposure. Here we provide the evidences that OCPs might disrupt root cell cycle leading to a rise in the level of polyploidy possibly through mechanisms of endoreduplication. In addition, low-to-high doses of γHCH were able to induce an accumulation of H2O2 without modifying NO contents, while CLD modulated neither H2O2 nor NO production. [Ca(2+)]cytosolic, the caspase-3-like activity as well as TUNEL-positive nuclei and IP-positive cells increased after exposure to low-to-high doses of OCPs. These data strongly suggest a cascade mechanism of the OCP-induced toxic effect, notably with an increase in [Ca(2+)]cytosolic and caspase-3-like activity, suggesting the activation of programmed cell death pathway.<br /> (Copyright © 2014 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-3336
- Volume :
- 276
- Database :
- MEDLINE
- Journal :
- Journal of hazardous materials
- Publication Type :
- Academic Journal
- Accession number :
- 24892778
- Full Text :
- https://doi.org/10.1016/j.jhazmat.2014.05.048