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Salicylate-induced auditory perceptual disorders and plastic changes in nonclassical auditory centers in rats.
- Source :
-
Neural plasticity [Neural Plast] 2014; Vol. 2014, pp. 658741. Date of Electronic Publication: 2014 May 07. - Publication Year :
- 2014
-
Abstract
- Previous studies have shown that sodium salicylate (SS) activates not only central auditory structures, but also nonauditory regions associated with emotion and memory. To identify electrophysiological changes in the nonauditory regions, we recorded sound-evoked local field potentials and multiunit discharges from the striatum, amygdala, hippocampus, and cingulate cortex after SS-treatment. The SS-treatment produced behavioral evidence of tinnitus and hyperacusis. Physiologically, the treatment significantly enhanced sound-evoked neural activity in the striatum, amygdala, and hippocampus, but not in the cingulate. The enhanced sound evoked response could be linked to the hyperacusis-like behavior. Further analysis showed that the enhancement of sound-evoked activity occurred predominantly at the midfrequencies, likely reflecting shifts of neurons towards the midfrequency range after SS-treatment as observed in our previous studies in the auditory cortex and amygdala. The increased number of midfrequency neurons would lead to a relative higher number of total spontaneous discharges in the midfrequency region, even though the mean discharge rate of each neuron may not increase. The tonotopical overactivity in the midfrequency region in quiet may potentially lead to tonal sensation of midfrequency (the tinnitus). The neural changes in the amygdala and hippocampus may also contribute to the negative effect that patients associate with their tinnitus.
- Subjects :
- Acoustic Stimulation
Amygdala physiology
Animals
Behavior, Animal physiology
Electrodes, Implanted
Evoked Potentials, Auditory drug effects
Gyrus Cinguli physiology
Hippocampus physiology
Loudness Perception physiology
Male
Neostriatum physiology
Rats
Rats, Sprague-Dawley
Reaction Time physiology
Reflex, Startle physiology
Tinnitus physiopathology
Auditory Perceptual Disorders chemically induced
Auditory Perceptual Disorders physiopathology
Neuronal Plasticity drug effects
Neuronal Plasticity physiology
Salicylates
Subjects
Details
- Language :
- English
- ISSN :
- 1687-5443
- Volume :
- 2014
- Database :
- MEDLINE
- Journal :
- Neural plasticity
- Publication Type :
- Academic Journal
- Accession number :
- 24891959
- Full Text :
- https://doi.org/10.1155/2014/658741