Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts.

Authors :: Veth CP
Arns M
Drinkenburg W
Talloen W
Peeters PJ
Gordon E
Buitelaar JK
Source :: Psychiatry research [Psychiatry Res] 2014 Sep 30; Vol. 219 (1), pp. 221-4. Date of Electronic Publication: 2014 May 20.
Publication Year :: 2014
Abstract: This study could not confirm the association between the Catechol-O-Methyltransferase Val158Met polymorphism (COMT) and electroencephalographic (EEG) alpha peak frequency (APF) in two independent cohorts of 187 (96 depressed and 91 healthy participants) and 413 healthy participants. If COMT and APF play a role in depression or antidepressant treatment response, they do not have a shared pathway. We emphasize the importance of publishing null-findings for obtaining more accurate overall estimates of genetic effects.<br /> (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)

Subjects :: Adult
Antidepressive Agents therapeutic use
Australia
Case-Control Studies
Cohort Studies
Depression drug therapy
Gene Frequency
Genotype
Humans
Male
Methionine genetics
Polymerase Chain Reaction
Prefrontal Cortex drug effects
Valine genetics
Catechol O-Methyltransferase genetics
Depression genetics
Electroencephalography methods
Polymorphism, Genetic

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