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General catalytic methylation of amines with formic acid under mild reaction conditions.
- Source :
-
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2014 Jun 23; Vol. 20 (26), pp. 7878-83. Date of Electronic Publication: 2014 May 28. - Publication Year :
- 2014
-
Abstract
- A general catalytic protocol for the methylation of amines has been developed applying, for the first time, formic acid as the C1 building block and silanes as reducing agents. A broad range of aromatic and aliphatic, both primary and secondary, amines has been converted to the corresponding tertiary amines including [N-(13)C]-labelled drugs in good to excellent yields under mild conditions.<br /> (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Catalysis
Methylation
Molecular Structure
Amines chemistry
Formates chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3765
- Volume :
- 20
- Issue :
- 26
- Database :
- MEDLINE
- Journal :
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 24889122
- Full Text :
- https://doi.org/10.1002/chem.201402124