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Predictors of success in selective laser trabeculoplasty for chinese open-angle glaucoma.
- Source :
-
Journal of glaucoma [J Glaucoma] 2014 Jun-Jul; Vol. 23 (5), pp. 321-5. - Publication Year :
- 2014
-
Abstract
- Aim: To investigate the determinants of success of selective laser trabeculoplasty (SLT) in Chinese open-angle glaucoma patients.<br />Methods: This prospective cohort study sequentially recruited Chinese subjects with unilateral or bilateral primary open-angle glaucoma (POAG) or normal tension glaucoma (NTG). All subjects received a single session of 360-degree SLT treatment. Success was defined as IOP reduction ≥20%. The following were analyzed in univariate and multivariate regression analyses for association with SLT success: type of glaucoma, age, sex, lens status, presenting IOP, pre-SLT IOP, day 1 IOP, 1-week IOP, number and type of anti-glaucoma medications, number of SLT shots and energy, retinal nerve fiber layer (RNFL) thickness, Visual Field Index, endothelial cell count, central corneal thickness, Snellen visual acuity, and spherical equivalent.<br />Results: In 111 eyes of 65 subjects, there were 51 POAG eyes and 60 NTG eyes. The overall success was 53.15% with a mean IOP reduction of 19.81±15.93%. In univariate analysis, a thinner RNFL [coefficient=-0.027; odds ratio (OR)=0.95; P=0.017] was associated with success. In multivariate analysis, a lower day 1 IOP (coefficient=-0.29; OR=0.75; P=0.049) and using topical carbonic anhydrase inhibitors (CAI) (coefficient=2.92; OR=18.63; P=0.0020) were associated with success. In both univariate and multivariate analyses, a higher pre-SLT IOP significantly predicted success (coefficient=0.20/0.46; OR=1.23/1.58; P=0.0017/0.0011) and using 3 anti-glaucoma medications (coefficient=-1.08/-3.74; OR=0.3/0.024; P=0.037/P=0.0081) was associated with SLT failure.<br />Conclusion: The positive predictors of SLT success included: higher pre-SLT IOP, use of topical CAI, thinner RNFL, and lower day 1 IOP. Using 3 anti-glaucoma medications was associated with failure.
- Subjects :
- Antihypertensive Agents therapeutic use
Asian People ethnology
Cell Count
Endothelium, Corneal pathology
Female
Glaucoma, Open-Angle ethnology
Humans
Intraocular Pressure physiology
Low Tension Glaucoma ethnology
Male
Middle Aged
Prognosis
Prospective Studies
Tonometry, Ocular
Visual Acuity physiology
Visual Fields physiology
Glaucoma, Open-Angle surgery
Laser Therapy methods
Lasers, Solid-State therapeutic use
Low Tension Glaucoma surgery
Trabeculectomy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1536-481X
- Volume :
- 23
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of glaucoma
- Publication Type :
- Academic Journal
- Accession number :
- 24886702
- Full Text :
- https://doi.org/10.1097/IJG.0000000000000049