[Candida spondylodiscitis. Report of 2 personal cases and 28 cases from the literature].

Vertebral osteomyelitis caused by Candida spp. has recently been described and seems to be rare since only 30 cases have been published so far. Its clinical, laboratory and radiological features are identical with those on non-tuberculous bacterial spondylitis. It develops in subjects with poor general condition who underwent multiple surgical operations or received prolonged antibiotic therapy. The finding of Candida at needle biopsy of the since clinches the diagnosis. Serological tests might provide an earlier diagnosis and, above all, enable therapeutic effectiveness to be evaluated. In 27 of the 30 cases reported here, cure was obtained by prolonged infusions of antifungal drugs, chiefly amphotericin B and/or 5-fluorocytosine.