Back to Search
Start Over
Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents.
- Source :
-
European journal of medicinal chemistry [Eur J Med Chem] 2014 Jun 23; Vol. 81, pp. 499-509. Date of Electronic Publication: 2014 May 14. - Publication Year :
- 2014
-
Abstract
- A series of novel indole-chalcone fibrates were synthesized and their hypolipidemic activity was evaluated in triton WR-1339 induced hyperlipidemic rat model. Preliminary studies indicated that the hybrids 19, 24 and 29 exhibited potent in vitro antioxidant and significant in vivo antidyslipidemic effects. Our results suggest that these new hybrid architectures may serve as promising leads for the development of next generation lipid lowering agents.<br /> (Copyright © 2014 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Animals
Antioxidants chemical synthesis
Antioxidants chemistry
Chalcone chemistry
Disease Models, Animal
Hyperlipidemias chemically induced
Hypolipidemic Agents chemical synthesis
Hypolipidemic Agents chemistry
Indoles chemistry
Lipoproteins blood
Lipoproteins, HDL blood
Lipoproteins, HDL metabolism
Lipoproteins, LDL blood
Lipoproteins, LDL metabolism
Male
Molecular Structure
Polyethylene Glycols administration & dosage
Rats
Antioxidants pharmacology
Chalcone pharmacology
Drug Design
Hyperlipidemias drug therapy
Hypolipidemic Agents pharmacology
Indoles pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1768-3254
- Volume :
- 81
- Database :
- MEDLINE
- Journal :
- European journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 24871900
- Full Text :
- https://doi.org/10.1016/j.ejmech.2014.04.085