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Ischemic burden by 3-dimensional myocardial perfusion cardiovascular magnetic resonance: comparison with myocardial perfusion scintigraphy.
- Source :
-
Circulation. Cardiovascular imaging [Circ Cardiovasc Imaging] 2014 Jul; Vol. 7 (4), pp. 647-54. Date of Electronic Publication: 2014 May 27. - Publication Year :
- 2014
-
Abstract
- Background: The extent and severity of ischemia on myocardial perfusion scintigraphy (MPS) is commonly used to risk-stratify patients with coronary artery disease. Estimation of ischemic burden by cardiovascular magnetic resonance (CMR) with conventional 2-dimensional myocardial perfusion methods is limited by incomplete cardiac coverage. More recently developed 3-dimensional (3D) myocardial perfusion CMR, however, provides whole-heart coverage. The aim of this study was to compare ischemic burden on 3D myocardial perfusion CMR with (99m)Tc-tetrofosmin MPS.<br />Methods and Results: Forty-five patients who had undergone clinically indicated MPS underwent rest and adenosine stress 3D myocardial perfusion and late gadolinium enhancement CMR. Summed stress and rest scores were calculated for MPS and CMR using a 17-segment model and expressed as a percentage of the maximal possible score. Ischemic burden was defined as the difference between stress and rest scores. 3D myocardial perfusion CMR and MPS agreed in 38 of the 45 patients for the detection of any inducible ischemia. The mean ischemic burden for MPS and CMR was similar (7.5±8.9% versus 6.8±9.5%, respectively, P=0.82) with a strong correlation between techniques (rs=0.70, P<0.001). In a subset of 33 patients who underwent clinically indicated invasive coronary angiography, sensitivities and specificities of the 2 techniques to detect angiographic coronary artery disease were similar (McNemar P=0.45).<br />Conclusions: 3D myocardial perfusion CMR is an alternative to MPS for detecting the presence and rating the severity of ischemia.<br /> (© 2014 American Heart Association, Inc.)
- Subjects :
- Adult
Aged
Female
Humans
Male
Middle Aged
ROC Curve
Reproducibility of Results
Severity of Illness Index
Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography methods
Coronary Artery Disease diagnosis
Heart diagnostic imaging
Imaging, Three-Dimensional
Magnetic Resonance Imaging, Cine methods
Myocardial Perfusion Imaging methods
Myocardium pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1942-0080
- Volume :
- 7
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Circulation. Cardiovascular imaging
- Publication Type :
- Academic Journal
- Accession number :
- 24867884
- Full Text :
- https://doi.org/10.1161/CIRCIMAGING.113.001620