Back to Search
Start Over
AS2077715: a novel antifungal antibiotic produced by Capnodium sp. 339855.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2014 Oct; Vol. 67 (10), pp. 707-11. Date of Electronic Publication: 2014 May 28. - Publication Year :
- 2014
-
Abstract
- A novel antifungal agent, AS2077715, was isolated from the fermentation broth of a fungal strain (339855) identified as a new Capnodium species based on morphological characteristics and large-subunit ribosomal DNA sequencing. AS2077715 was isolated as a white powder via solvent extraction, HP-20 and ODS-B column chromatography and crystallization, and was determined to have the molecular formula C25H41NO7. AS2077715 has a structure related to that of funiculosin, an inhibitor of mitochondrial cytochrome bc1 complex (complex III), and showed antifungal activity against Trichophyton species.
- Subjects :
- Ascomycota classification
Ascomycota genetics
Ascomycota growth & development
Cluster Analysis
DNA, Fungal chemistry
DNA, Fungal genetics
DNA, Ribosomal chemistry
DNA, Ribosomal genetics
Enzyme Inhibitors isolation & purification
Enzyme Inhibitors pharmacology
Fermentation
Genes, rRNA
Magnetic Resonance Spectroscopy
Molecular Sequence Data
Molecular Structure
Phylogeny
RNA, Fungal genetics
RNA, Ribosomal genetics
Sequence Analysis, DNA
Trichophyton drug effects
Antifungal Agents isolation & purification
Antifungal Agents pharmacology
Ascomycota metabolism
Biological Products isolation & purification
Biological Products pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1881-1469
- Volume :
- 67
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 24865863
- Full Text :
- https://doi.org/10.1038/ja.2014.69