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Breast cancer micrometastasis and axillary sentinel lymph nodes frozen section. Our experience and review of literature.
- Source :
-
International journal of surgery (London, England) [Int J Surg] 2014; Vol. 12 Suppl 1, pp. S12-5. Date of Electronic Publication: 2014 May 22. - Publication Year :
- 2014
-
Abstract
- Background: Sentinel lymph node (SLN) biopsy plays a major role in the surgical management of primary breast cancer. The aim of this study was to assess the diagnostic accuracy of the assessment of axillary frozen sections of SLNs for micrometastasis diagnosis.<br />Patients and Methods: This study focused on 250 SLNs from 137 patients. Each lymph node was fully analyzed by frozen section. After fixation, serial sections were cut and stained by hematoxylin and eosin (HE) and for pan-cytokeratins by immunohistochemistry (IHC).<br />Results: Tumor cells were detected in 57 SLNs, 37 on frozen sections and 20 on controls. Of these 57 positive SLNs, 38 contained metastases, 9 contained micrometastases and 10 contained isolated tumor cells. The specificity and positive predictive value of SLN frozen sections for micrometastasis was 100%. The sensitivity was 83.3% for metastasis, 40% for micrometastasis; the false-negative rate was 16.7% for metastasis and 60% for micrometastasis.<br />Conclusion: Analysis of frozen section of SLNs is an accurate method for metastasis detection, allowing concurrent axillary dissection when positive. The protocol for SLN analyses described herein shows good sensitivity for micrometastasis detection.<br /> (Copyright © 2014. Published by Elsevier Ltd.)
- Subjects :
- Axilla
Breast Neoplasms surgery
False Negative Reactions
Female
Frozen Sections methods
Humans
Lymph Node Excision
Lymphatic Metastasis
Neoplasm Micrometastasis therapy
Retrospective Studies
Sensitivity and Specificity
Breast Neoplasms pathology
Neoplasm Micrometastasis pathology
Sentinel Lymph Node Biopsy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1743-9159
- Volume :
- 12 Suppl 1
- Database :
- MEDLINE
- Journal :
- International journal of surgery (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 24859398
- Full Text :
- https://doi.org/10.1016/j.ijsu.2014.05.044