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Synthesis, preliminary bioevaluation and computational analysis of caffeic acid analogues.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2014 May 16; Vol. 15 (5), pp. 8808-20. Date of Electronic Publication: 2014 May 16. - Publication Year :
- 2014
-
Abstract
- A series of caffeic acid amides were designed, synthesized and evaluated for anti-inflammatory activity. Most of them exhibited promising anti-inflammatory activity against nitric oxide (NO) generation in murine macrophage RAW264.7 cells. A 3D pharmacophore model was created based on the biological results for further structural optimization. Moreover, predication of the potential targets was also carried out by the PharmMapper server. These amide analogues represent a promising class of anti-inflammatory scaffold for further exploration and target identification.
- Subjects :
- Animals
Anti-Inflammatory Agents chemistry
Anti-Inflammatory Agents metabolism
Binding Sites
Caffeic Acids chemical synthesis
Caffeic Acids metabolism
Catalytic Domain
Cell Line
Mice
Molecular Docking Simulation
Nitric Oxide metabolism
Orotidine-5'-Phosphate Decarboxylase chemistry
Orotidine-5'-Phosphate Decarboxylase metabolism
Phosphorus-Oxygen Lyases genetics
Phosphorus-Oxygen Lyases metabolism
Protein Binding
Proto-Oncogene Proteins p21(ras) genetics
Proto-Oncogene Proteins p21(ras) metabolism
Structure-Activity Relationship
Anti-Inflammatory Agents chemical synthesis
Caffeic Acids chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 15
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 24857914
- Full Text :
- https://doi.org/10.3390/ijms15058808