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Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection.
- Source :
-
Science (New York, N.Y.) [Science] 2014 May 23; Vol. 344 (6186), pp. 871-7. - Publication Year :
- 2014
-
Abstract
- Novel vaccines are urgently needed to reduce the burden of severe malaria. Using a differential whole-proteome screening method, we identified Plasmodium falciparum schizont egress antigen-1 (PfSEA-1), a 244-kilodalton parasite antigen expressed in schizont-infected red blood cells (RBCs). Antibodies to PfSEA-1 decreased parasite replication by arresting schizont rupture, and conditional disruption of PfSEA-1 resulted in a profound parasite replication defect. Vaccination of mice with recombinant Plasmodium berghei PbSEA-1 significantly reduced parasitemia and delayed mortality after lethal challenge with the Plasmodium berghei strain ANKA. Tanzanian children with antibodies to recombinant PfSEA-1A (rPfSEA-1A) did not experience severe malaria, and Kenyan adolescents and adults with antibodies to rPfSEA-1A had significantly lower parasite densities than individuals without these antibodies. By blocking schizont egress, PfSEA-1 may synergize with other vaccines targeting hepatocyte and RBC invasion.<br /> (Copyright © 2014, American Association for the Advancement of Science.)
- Subjects :
- Adolescent
Adult
Animals
Antibodies, Protozoan blood
Child
Hepatocytes immunology
Hepatocytes parasitology
Humans
Immunoglobulin G blood
Immunoglobulin G immunology
Kenya
Malaria prevention & control
Mice
Plasmodium berghei immunology
Plasmodium falciparum immunology
Recombinant Proteins immunology
Young Adult
Antibodies, Protozoan immunology
Antigens, Protozoan immunology
Erythrocytes parasitology
Malaria Vaccines immunology
Malaria, Falciparum prevention & control
Plasmodium falciparum growth & development
Protozoan Proteins immunology
Schizonts growth & development
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 344
- Issue :
- 6186
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 24855263
- Full Text :
- https://doi.org/10.1126/science.1254417