Back to Search
Start Over
δ-Aminolevulinate dehydratase activity in lung cancer patients and its relationship with oxidative stress.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2014 Jun; Vol. 68 (5), pp. 603-9. Date of Electronic Publication: 2014 Apr 28. - Publication Year :
- 2014
-
Abstract
- This study investigated the δ-aminolevulinate dehydratase (δ-ALA-D) activity in whole blood as well as the parameters of oxidative stress, such as reactive species (RS) levels in serum, thiobarbituric acid reactive substances (TBARS) levels, the superoxide dismutase (SOD) and catalase (CAT) activities, as well as total thiols (T-SH) and non-protein thiols (NPSH) levels in platelets. Moreover, the content of vitamin C and E in plasma and serum, respectively, in lung cancer patients was also investigated. We collected blood samples from patients (n=28) previously treated for lung cancer with chemotherapy. Patients were classified as stage IIIb and IV according to the Union for International Cancer Control (UICC). Results showed a decrease of 37% in δ-ALA-D activity in patients with lung cancer when compared to the control group. RS and TBARS levels were 8% and 99% higher in the patient group, respectively. The activity of SOD and CAT as well as the vitamin C content were 41%, 35% and 127% lower in patients when compared with controls, respectively. However, T-SH and vitamin E levels were 27% and 44% higher in lung cancer patients, respectively. Results show that the overproduction of reactive species in patients with lung cancer may be interfering with the activity of δ-ALA-D. Likewise, the decrease in the activity of this enzyme may be contributing for the oxidative stress.<br /> (Copyright © 2014 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Aged
Ascorbic Acid blood
Blood Platelets enzymology
Case-Control Studies
Catalase blood
Cisplatin pharmacology
Cisplatin therapeutic use
Deoxycytidine analogs & derivatives
Deoxycytidine pharmacology
Deoxycytidine therapeutic use
Female
Humans
Lung Neoplasms blood
Lung Neoplasms drug therapy
Male
Middle Aged
Reactive Oxygen Species metabolism
Sulfhydryl Compounds blood
Superoxide Dismutase blood
Thiobarbituric Acid Reactive Substances metabolism
Vitamin E blood
Gemcitabine
Lung Neoplasms enzymology
Lung Neoplasms pathology
Oxidative Stress drug effects
Porphobilinogen Synthase metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1950-6007
- Volume :
- 68
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 24855033
- Full Text :
- https://doi.org/10.1016/j.biopha.2014.04.005