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Palladium-catalyzed direct addition of 2-aminobenzonitriles to sodium arylsulfinates: synthesis of o-aminobenzophenones.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2014 May 20; Vol. 19 (5), pp. 6439-49. Date of Electronic Publication: 2014 May 20. - Publication Year :
- 2014
-
Abstract
- The first example of the palladium-catalyzed synthesis of o-aminobenzophenones in moderate to excellent yields via a direct addition of sodium arylsulfinates to unprotected 2-aminobenzonitriles was reported. A plausible mechanism for the formation of o-aminobenzophenones involving desulfination and addition reactions was proposed. The utility of this transformation was demonstrated by its compatibility with a wide range of functional groups. Thus, the method represents a convenient and practical strategy for synthesis of o-aminobenzophenones.
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 19
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 24853617
- Full Text :
- https://doi.org/10.3390/molecules19056439