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Capillary Index Score in the Interventional Management of Stroke trials I and II.
- Source :
-
Stroke [Stroke] 2014 Jul; Vol. 45 (7), pp. 1999-2003. Date of Electronic Publication: 2014 May 22. - Publication Year :
- 2014
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Abstract
- Background and Purpose: The Capillary Index Score (CIS) is a simple angiography-based scale for assessing viable tissue in the ischemic territory. We retrospectively applied it to Interventional Management of Stroke (IMS) trials I and II to evaluate the predictive value for good outcomes.<br />Methods: CIS was calculated from pretreatment diagnostic cerebral angiograms blinded to outcome. IMS I and II diagnostic cerebral angiogram images of sufficient quality were reviewed and CIS calculated for treated subjects with internal carotid artery or M1 occlusion. CIS scoring (0-3) was dichotomized into favorable (f CIS; 2 or 3) and poor (p CIS; 0 or 1). Modified thrombolysis in cerebral infarction score 2b or 3 was considered good revascularization. CIS and modified thrombolysis in cerebral infarction scores were compared with good outcome, defined as modified Rankin Scale score≤2 at 90 days.<br />Results: Twenty-eight of 161 subjects met the inclusion criteria. Thirteen (46%) had f CIS. Good clinical outcome was significantly different between the 2 CIS groups (62% for f CIS versus 7% for p CIS; P=0.004). Good reperfusion correlated to good outcome (P=0.04). No significant differences in time to intravenous or intra-arterial treatment were identified between f CIS and p CIS groups (P>0.25).<br />Conclusions: A f CIS was found in ≈50% of subjects and was a virtual prerequisite for good outcome in this study subgroup of IMS I and II. We call this the 50% barrier.<br /> (© 2014 American Heart Association, Inc.)
- Subjects :
- Aged
Brain Ischemia diagnostic imaging
Brain Ischemia therapy
Carotid Artery Diseases diagnostic imaging
Carotid Artery Diseases pathology
Carotid Artery Diseases therapy
Cerebral Infarction diagnostic imaging
Cerebral Infarction pathology
Cerebral Infarction therapy
Clinical Trials as Topic
Disease Management
Female
Fibrinolytic Agents administration & dosage
Humans
Male
Middle Aged
Predictive Value of Tests
Prognosis
Retrospective Studies
Severity of Illness Index
Single-Blind Method
Stroke diagnostic imaging
Stroke therapy
Brain Ischemia pathology
Capillaries diagnostic imaging
Cerebral Angiography statistics & numerical data
Fibrinolytic Agents pharmacology
Stroke pathology
Thrombolytic Therapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4628
- Volume :
- 45
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Stroke
- Publication Type :
- Academic Journal
- Accession number :
- 24851874
- Full Text :
- https://doi.org/10.1161/STROKEAHA.114.005304