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The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study.
- Source :
-
Annals of the rheumatic diseases [Ann Rheum Dis] 2015 Oct; Vol. 74 (10), pp. 1842-7. Date of Electronic Publication: 2014 May 20. - Publication Year :
- 2015
-
Abstract
- Objective: To study the relative contribution of surrogates for mechanical stress and systemic processes with osteoarthritis (OA) in weight-bearing and non-weight-bearing joints.<br />Methods: The Netherlands Epidemiology of Obesity study is a population-based cohort including 6673 participants (range 45-65 years, 56% women, median body mass index 26 kg/m(2)). Weight (kg) and fat mass (kg) were measured, fat-free mass (kg) was calculated. The metabolic syndrome was defined following the Adult Treatment Panel III criteria. Knee and hand OA were defined according to the American College of Rheumatology clinical criteria.Logistic regression analyses were performed to associate surrogates for mechanical stress (such as weight, fat-free mass) and systemic processes (such as metabolic syndrome) with OA in knees alone, knees and hands or hands alone, adjusted for age, sex, height, smoking, education and ethnicity, and when appropriate for metabolic factors and weight.<br />Results: Knee, knee and hand, and hand OA were present in 10%, 4% and 8% of the participants, respectively. Knee OA was associated with weight and fat-free mass, adjusted for metabolic factors (OR 1.49 (95% CI 1.32 to 1.68) and 2.05 (1.60 to 2.62), respectively). Similar results were found for OA in knees and hands (OR 1.51 (95% CI 1.29 to 1.78) and 2.17 (95% CI 1.52 to 3.10) respectively). Hand OA was associated with the metabolic syndrome, adjusted for weight (OR 1.46 (95% CI 1.06 to 2.02)).<br />Conclusions: In knee OA, whether or not in co-occurrence with hand OA, surrogates for mechanical stress are suggested to be the most important risk factors, whereas in hand OA alone, surrogates for systemic processes are the most important risk factors.<br /> (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.)
- Subjects :
- Body Composition physiology
Body Weight physiology
Cross-Sectional Studies
Female
Hand Joints physiopathology
Humans
Male
Metabolic Syndrome complications
Metabolic Syndrome epidemiology
Metabolic Syndrome physiopathology
Middle Aged
Netherlands epidemiology
Osteoarthritis epidemiology
Osteoarthritis etiology
Osteoarthritis, Knee epidemiology
Osteoarthritis, Knee etiology
Osteoarthritis, Knee physiopathology
Stress, Mechanical
Weight-Bearing physiology
Osteoarthritis physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1468-2060
- Volume :
- 74
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Annals of the rheumatic diseases
- Publication Type :
- Academic Journal
- Accession number :
- 24845389
- Full Text :
- https://doi.org/10.1136/annrheumdis-2013-205012