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Sesquiterpenoids from Pittocaulon filare.
- Source :
-
Journal of natural products [J Nat Prod] 2014 Jun 27; Vol. 77 (6), pp. 1304-10. Date of Electronic Publication: 2014 May 19. - Publication Year :
- 2014
-
Abstract
- The phytochemical study of Pittocaulon filare afforded three oplopanes (1-3), a eudesmane (6), and three oplopane glucosides (7-9), one of them reported as its acetyl derivative (7a), together with several known compounds. The structures of the compounds were elucidated by spectroscopic analysis and chemical reactions. The anti-inflammatory activity of compounds 1-5 was determined using the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema model, and the effect of compounds 1-4 on the recruitment of neutrophils was evaluated using the myeloperoxidase test. Compounds 1 and 2 were the more active anti-inflammatory agents, with lower ID50 values (0.17 and 0.18 μmol/ear, respectively) than indomethacin (0.24 μmol/ear), but they had a lesser effect on the inhibition of neutrophil infiltration than both indomethacin and compound 3, indicating that the tested compounds do not have the same ability to inhibit edema and to prevent cell infiltration.
- Subjects :
- Animals
Anti-Inflammatory Agents chemistry
Anti-Inflammatory Agents pharmacology
Disease Models, Animal
Edema chemically induced
Edema drug therapy
Glucosides adverse effects
Glucosides therapeutic use
Indomethacin adverse effects
Indomethacin therapeutic use
Mexico
Neutrophil Infiltration drug effects
Neutrophils metabolism
Nuclear Magnetic Resonance, Biomolecular
Peroxidase metabolism
Sesquiterpenes chemistry
Sesquiterpenes pharmacology
Stereoisomerism
Tetradecanoylphorbol Acetate pharmacology
Asteraceae chemistry
Sesquiterpenes isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 77
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 24842703
- Full Text :
- https://doi.org/10.1021/np401033h