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Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
- Source :
-
Nature genetics [Nat Genet] 2014 Jun; Vol. 46 (6), pp. 533-42. Date of Electronic Publication: 2014 May 18. - Publication Year :
- 2014
-
Abstract
- Known genetic loci explain only a small proportion of the familial relative risk of colorectal cancer (CRC). We conducted a genome-wide association study of CRC in East Asians with 14,963 cases and 31,945 controls and identified 6 new loci associated with CRC risk (P = 3.42 × 10(-8) to 9.22 × 10(-21)) at 10q22.3, 10q25.2, 11q12.2, 12p13.31, 17p13.3 and 19q13.2. Two of these loci map to genes (TCF7L2 and TGFB1) with established roles in colorectal tumorigenesis. Four other loci are located in or near genes involved in transcriptional regulation (ZMIZ1), genome maintenance (FEN1), fatty acid metabolism (FADS1 and FADS2), cancer cell motility and metastasis (CD9), and cell growth and differentiation (NXN). We also found suggestive evidence for three additional loci associated with CRC risk near genome-wide significance at 8q24.11, 10q21.1 and 10q24.2. Furthermore, we replicated 22 previously reported CRC-associated loci. Our study provides insights into the genetic basis of CRC and suggests the involvement of new biological pathways.
- Subjects :
- Asian People genetics
Case-Control Studies
China
Chromosome Mapping
Computational Biology
Delta-5 Fatty Acid Desaturase
Female
Gene Expression Profiling
Genetic Predisposition to Disease
Genetic Variation
Genotype
Humans
Japan
Male
Neoplasm Metastasis
Polymorphism, Single Nucleotide
Republic of Korea
Risk
Colorectal Neoplasms ethnology
Colorectal Neoplasms genetics
Genetic Loci
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 46
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 24836286
- Full Text :
- https://doi.org/10.1038/ng.2985