Back to Search
Start Over
Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE).
- Source :
-
Environmental health perspectives [Environ Health Perspect] 2014 Sep; Vol. 122 (9), pp. 896-905. Date of Electronic Publication: 2014 May 16. - Publication Year :
- 2014
-
Abstract
- Background: Long-term exposure to air pollution has been hypothesized to elevate arterial blood pressure (BP). The existing evidence is scarce and country specific.<br />Objectives: We investigated the cross-sectional association of long-term traffic-related air pollution with BP and prevalent hypertension in European populations.<br />Methods: We analyzed 15 population-based cohorts, participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE). We modeled residential exposure to particulate matter and nitrogen oxides with land use regression using a uniform protocol. We assessed traffic exposure with traffic indicator variables. We analyzed systolic and diastolic BP in participants medicated and nonmedicated with BP-lowering medication (BPLM) separately, adjusting for personal and area-level risk factors and environmental noise. Prevalent hypertension was defined as ≥ 140 mmHg systolic BP, or ≥ 90 mmHg diastolic BP, or intake of BPLM. We combined cohort-specific results using random-effects meta-analysis.<br />Results: In the main meta-analysis of 113,926 participants, traffic load on major roads within 100 m of the residence was associated with increased systolic and diastolic BP in nonmedicated participants [0.35 mmHg (95% CI: 0.02, 0.68) and 0.22 mmHg (95% CI: 0.04, 0.40) per 4,000,000 vehicles × m/day, respectively]. The estimated odds ratio (OR) for prevalent hypertension was 1.05 (95% CI: 0.99, 1.11) per 4,000,000 vehicles × m/day. Modeled air pollutants and BP were not clearly associated.<br />Conclusions: In this first comprehensive meta-analysis of European population-based cohorts, we observed a weak positive association of high residential traffic exposure with BP in nonmedicated participants, and an elevated OR for prevalent hypertension. The relationship of modeled air pollutants with BP was inconsistent.
- Subjects :
- Air Pollutants analysis
Air Pollution statistics & numerical data
Antihypertensive Agents therapeutic use
Cross-Sectional Studies
Environmental Exposure analysis
Europe epidemiology
Female
Humans
Male
Nitrogen Oxides analysis
Nitrogen Oxides toxicity
Noise, Transportation statistics & numerical data
Particulate Matter analysis
Risk Factors
Vehicle Emissions analysis
Air Pollutants toxicity
Arterial Pressure
Environmental Exposure statistics & numerical data
Hypertension chemically induced
Hypertension epidemiology
Particulate Matter toxicity
Vehicle Emissions toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1552-9924
- Volume :
- 122
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Environmental health perspectives
- Publication Type :
- Academic Journal
- Accession number :
- 24835507
- Full Text :
- https://doi.org/10.1289/ehp.1307725