Back to Search
Start Over
Anticancer activity of new depsipeptide compound isolated from an endophytic fungus.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2014 Oct; Vol. 67 (10), pp. 697-701. Date of Electronic Publication: 2014 May 14. - Publication Year :
- 2014
-
Abstract
- A novel depsipeptide (PM181110) was purified from an endophytic fungus Phomopsis glabrae isolated from the leaves of Pongamia pinnata (family Fabaceae). The chemical structure of PM181110 was elucidated using physiochemical properties, 2D NMR and other spectroscopic methods. PM181110 is very close in structure to FE399. The compound exhibited in vitro anticancer activity against 40 human cancer cell lines with a mean IC50 value of 0.089 μM and ex vivo efficacy towards 24 human tumor xenografts (mean IC50=0.245 μM).
- Subjects :
- Antineoplastic Agents chemistry
Antineoplastic Agents isolation & purification
Ascomycota isolation & purification
Biological Products chemistry
Biological Products isolation & purification
Cell Line, Tumor
Chemical Phenomena
Depsipeptides chemistry
Depsipeptides isolation & purification
Endophytes isolation & purification
Humans
Inhibitory Concentration 50
Millettia microbiology
Molecular Structure
Plant Leaves microbiology
Spectrum Analysis
Antineoplastic Agents pharmacology
Ascomycota chemistry
Biological Products pharmacology
Depsipeptides pharmacology
Endophytes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1881-1469
- Volume :
- 67
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 24824817
- Full Text :
- https://doi.org/10.1038/ja.2014.58