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Effect of long-term dietary arginyl-fructose (AF) on hyperglycemia and HbA1c in diabetic db/db mice.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2014 May 12; Vol. 15 (5), pp. 8352-9. Date of Electronic Publication: 2014 May 12. - Publication Year :
- 2014
-
Abstract
- We have previously reported that Amadori compounds exert anti-diabetic effects by lowering sucrose-induced hyperglycemia in normal Sprague-Dawley rats. In the present study we extended our recent findings to evaluate whether α-glucosidase inhibitor arginyl-fructose (AF) lowers blood glucose level in diabetic db/db mice, a genetic model for type 2 diabetes. The db/db mice were randomly assigned to high-carbohydrate diets (66.1% corn starch) with and without AF (4% in the diet) for 6 weeks. Changes in body weight, blood glucose level, and food intake were measured daily for 42 days. Dietary supplementation of AF resulted in a significant decrease of blood glucose level (p < 0.001) and body weight (p < 0.001). The level of HbA1c, a better indicator of plasma glucose concentration over prolonged periods of time, was also significantly decreased for 6-week period (p < 0.001). Dietary treatment of acarbose® (0.04% in diet), a positive control, also significantly alleviated the level of blood glucose, HbA1c, and body weight. These results indicate that AF Maillard reaction product improves postprandial hyperglycemia by suppressing glucose absorption as well as decreasing HbA1c level.
- Subjects :
- Animals
Blood Glucose drug effects
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 complications
Dietary Supplements analysis
Glycoside Hydrolase Inhibitors chemistry
Hyperglycemia blood
Hyperglycemia complications
Hypoglycemic Agents chemistry
Hypoglycemic Agents therapeutic use
Male
Mice
Mice, Inbred C57BL
Diabetes Mellitus, Type 2 diet therapy
Fructose analogs & derivatives
Fructose therapeutic use
Glycated Hemoglobin analysis
Glycoside Hydrolase Inhibitors therapeutic use
Hyperglycemia diet therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 15
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 24823880
- Full Text :
- https://doi.org/10.3390/ijms15058352