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Reference absolute and indexed values for left and right ventricular volume, function and mass from cardiac computed tomography.
- Source :
-
Journal of medical imaging and radiation oncology [J Med Imaging Radiat Oncol] 2014 Oct; Vol. 58 (5), pp. 547-58. Date of Electronic Publication: 2014 May 13. - Publication Year :
- 2014
-
Abstract
- Introduction: Left ventricular (LV) and right ventricular (RV) volumetric and functional parameters are important biomarkers for morbidity and mortality in patients with heart failure.<br />Purpose: To retrospectively determine reference mean values of LV and RV volume, function and mass normalised by age, gender and body surface area (BSA) from retrospectively electrocardiographically gated 64-slice cardiac computed tomography (CCT) by using automated analysis software in healthy adults.<br />Materials and Methods: The study was approved by the institutional review board with a waiver of informed consent. Seventy-four healthy subjects (49% female, mean age 49.6 ± 11) free of hypertension and hypercholesterolaemia with a normal CCT formed the study population. Analyses of LV and RV volume (end-diastolic, end-systolic and stroke volumes), function (ejection fraction), LV mass and inter-rater reproducibility were performed with commercially available analysis software capable of automated contour detection. General linear model analysis was performed to assess statistical significance by age group after adjustment for gender and BSA. Bland-Altman analysis assessed the inter-rater agreement.<br />Results: The reference range for LV and RV volume, function, and LV mass was normalised to age, gender and BSA. Statistically significant differences were noted between genders in both LV mass and RV volume (P-value < 0.0001). Age, in concert with gender, was associated with significant differences in RV end-diastolic volume and LV ejection fraction (P-values 0.027 and 0.03). Bland-Altman analysis showed acceptable limits of agreement (±1.5% for ejection fraction) without systematic error.<br />Conclusion: LV and RV volume, function and mass normalised to age, gender and BSA can be reported from CCT datasets, providing additional information important for patient management.<br /> (© 2014 The Royal Australian and New Zealand College of Radiologists.)
- Subjects :
- Adult
Aged
Female
Humans
Male
Middle Aged
Observer Variation
Organ Size physiology
Reference Values
Reproducibility of Results
Sensitivity and Specificity
Sex Characteristics
United States
Aging physiology
Body Surface Area
Heart Ventricles diagnostic imaging
Radiographic Image Interpretation, Computer-Assisted standards
Stroke Volume physiology
Tomography, X-Ray Computed standards
Ventricular Function physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1754-9485
- Volume :
- 58
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of medical imaging and radiation oncology
- Publication Type :
- Academic Journal
- Accession number :
- 24821646
- Full Text :
- https://doi.org/10.1111/1754-9485.12186