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Risk stratification of arrhythmogenic right ventricular cardiomyopathy based on signal averaged electrocardiograms.
- Source :
-
International journal of cardiology [Int J Cardiol] 2014 Jul 01; Vol. 174 (3), pp. 628-33. Date of Electronic Publication: 2014 Apr 21. - Publication Year :
- 2014
-
Abstract
- Background: Signal averaged electrocardiogram (SAECG) is a specific and non-invasive tool useful for arrhythmogenic right ventricular cardiomyopathy (ARVC) diagnosis. However, its role in risk stratification of patients with ARVC remains largely undefined.<br />Methods: Sixty-four patients fulfilling Task Force ARVC criteria (mean age: 47 ± 14 years-old, 56% male, 50% definite ARVC) were enrolled. The baseline demographic, electrocardiographic, structural, and electrophysiological characteristics were collected. Patients with SAECG fulfilling all 3 Task Force criteria (3+ SAECG) were categorized into group 1, and those fulfilled 2 or less criterion were categorized into group 2. The study endpoints were unstable ventricular arrhythmia (VA), device detectable sustained fast VA (cycle lengths < 240 ms) and cardiovascular death.<br />Results: During a mean follow-up of 21 ± 20 months, 15 primary endpoints including 12 unstable VAs and 3 device-detected fast VAs were met. One patient died of electrical storm, and one patient underwent heart transplantation. The presence of 3+ SAECG predicted malignant events in all patients with definite and non-definite ARVC (p < 0.01, OR = 30.5, 95% CI = 2.5-373.7) and in patients with definite ARVC alone (p = 0.03, OR = 11.1, 95% CI = 1.3-93.9). Patients diagnosed with non-definite ARVC without 3+ SAECG were free from malignant events.<br />Conclusions: SAECG fulfilling all 3 Task Force criteria was an independent risk predictor of malignant events in ARVC patients. SAECG may play a valuable role in ARVC risk stratification.<br /> (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Arrhythmogenic Right Ventricular Dysplasia therapy
Cohort Studies
Disease-Free Survival
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prospective Studies
Risk Factors
Arrhythmogenic Right Ventricular Dysplasia diagnosis
Arrhythmogenic Right Ventricular Dysplasia physiopathology
Electrocardiography methods
Subjects
Details
- Language :
- English
- ISSN :
- 1874-1754
- Volume :
- 174
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 24820746
- Full Text :
- https://doi.org/10.1016/j.ijcard.2014.04.169