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Ethical issues raised by whole genome sequencing.

Ethical issues raised by whole genome sequencing.

Authors :
Pinxten W
Howard HC
Source :
Best practice & research. Clinical gastroenterology [Best Pract Res Clin Gastroenterol] 2014 Apr; Vol. 28 (2), pp. 269-79. Date of Electronic Publication: 2014 Mar 12.
Publication Year :
2014

Abstract

While there is ongoing discussion about the details of implementation of whole genome sequencing (WGS) and whole exome sequencing (WES), there appears to be a consensus amongst geneticists that the widespread use of these approaches is not only inevitable, but will also be beneficial [1]. However, at the present time, we are unable to anticipate the full range of uses, consequences and impact of implementing WGS and WES. Nevertheless, the already known ethical issues, both in research and in clinical practice are diverse and complex and should be addressed properly presently. Herein, we discuss the ethical aspects of WGS and WES by particularly focussing on three overlapping themes: (1) informed consent, (2) data handling, and (3) the return of results.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1532-1916
Volume :
28
Issue :
2
Database :
MEDLINE
Journal :
Best practice & research. Clinical gastroenterology
Publication Type :
Academic Journal
Accession number :
24810188
Full Text :
https://doi.org/10.1016/j.bpg.2014.02.004