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Electrophysiological expression of endothelin and angiotensin receptors in Xenopus oocytes injected with rat heart mRNA.
- Source :
-
FEBS letters [FEBS Lett] 1989 Dec 04; Vol. 258 (2), pp. 289-92. - Publication Year :
- 1989
-
Abstract
- Functional endothelin and angiotensin receptors have been expressed in Xenopus oocyte following the microinjection of rat heart mRNA. Under voltage clamp conditions, application of these peptides clearly induced oscillatory Ca2+-activated chloride currents in a dose-dependent manner. In addition, no direct modulation of expressed or native cardiac Ca channels was observed.
- Subjects :
- Animals
Chloride Channels
Electric Conductivity
Endothelins
Endothelium, Vascular physiology
Female
Heart Ventricles drug effects
Ion Channels drug effects
Kinetics
Microinjections
Oocytes drug effects
Oocytes metabolism
Rats
Receptors, Angiotensin physiology
Receptors, Cell Surface physiology
Receptors, Endothelin
Ventricular Function
Xenopus
Angiotensin II pharmacology
Chlorides physiology
Gene Expression
Ion Channels physiology
Membrane Proteins physiology
Myocardium metabolism
Oocytes physiology
Peptides pharmacology
RNA, Messenger genetics
Receptors, Angiotensin genetics
Receptors, Cell Surface genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0014-5793
- Volume :
- 258
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 2480916
- Full Text :
- https://doi.org/10.1016/0014-5793(89)81676-x