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Comparison of Efficacy and Tolerability of Hylan G-F 20 in Patients with and without Effusions at the Time of Initial Injection.
- Source :
-
The journal of knee surgery [J Knee Surg] 2015 Jun; Vol. 28 (3), pp. 213-22. Date of Electronic Publication: 2014 May 07. - Publication Year :
- 2015
-
Abstract
- An effusion at the onset of viscosupplementation has been thought to diminish the efficacy and increase adverse event rates. This study compares efficacy of hylan G-F 20 in patients with and without an effusion. Patients with knee osteoarthritis (OA) received three weekly injections of hylan G-F 20. A total of 50 patients with an effusion requiring aspiration were compared with 50 matched patients without an effusion. Outcome measurements included Western Ontario and McMaster's Universities Osteoarthritis index (WOMAC) and visual analog scale (VAS). Patients were followed for 26 weeks. Both effusion and control group VAS was significantly lowered at all time points. WOMAC scores improved (p < 0.025) at all visits in the effusion group except for WOMAC A-1 week 14. Control WOMAC scores also significantly improved at all visits (p < 0.027), except for full WOMAC and WOMAC A-1 at week 1. Neither group experienced an adverse event. Presence of an effusion at onset of viscosupplementation requiring aspiration does not negatively impact efficacy of hylan G-F 20 or increase adverse event rates.<br /> (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.)
- Subjects :
- Aged
Aged, 80 and over
Female
Humans
Hyaluronic Acid administration & dosage
Injections, Intra-Articular
Male
Middle Aged
Retrospective Studies
Suction
Treatment Outcome
Viscosupplementation
Hyaluronic Acid analogs & derivatives
Hydrarthrosis therapy
Osteoarthritis, Knee therapy
Viscosupplements administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1938-2480
- Volume :
- 28
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The journal of knee surgery
- Publication Type :
- Academic Journal
- Accession number :
- 24807194
- Full Text :
- https://doi.org/10.1055/s-0034-1376328