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Yeast oropharyngeal colonization in human immunodeficiency virus-infected patients in central taiwan.
- Source :
-
Mycopathologia [Mycopathologia] 2014 Jun; Vol. 177 (5-6), pp. 309-17. Date of Electronic Publication: 2014 May 08. - Publication Year :
- 2014
-
Abstract
- A prospective, cross-sectional study was conducted at a medical center in central Taiwan to understand the prevalence, associated factors, and microbiologic features for oropharyngeal yeast colonization in human immunodeficiency virus-infected outpatients. Oral yeast colonization was detected in 127 (45 %) patients, including 21 (16.5 %) colonized by more than one species. Of the 154 isolates, Candida albicans was the most common species (114, 74 %), followed by Candida dubliniensis (10, 6.5 %), Candida glabrata (10, 6.5 %), Candida tropicalis (7, 4.5 %), and 13 others. We found that receiving antituberculous drug (p = 0.046) or atazanavir (p = 0.045) was two predictors for patients colonized by non-C. albicans species (p = 0.005) and risking mixed yeast colonization (p = 0.009). Even though our data showed that clinical antifungal drugs remained effective in vitro against the colonizing yeasts, the increased mixed yeast colonization indicates a potential issue for controlling mixed infections in hospital settings.
- Subjects :
- AIDS-Related Opportunistic Infections drug therapy
AIDS-Related Opportunistic Infections immunology
Adult
Antifungal Agents therapeutic use
CD4 Lymphocyte Count
Candida classification
Candida drug effects
Candida genetics
Candidiasis drug therapy
Candidiasis immunology
Cross-Sectional Studies
Female
Fluconazole therapeutic use
Humans
Male
Middle Aged
Prospective Studies
Taiwan
AIDS-Related Opportunistic Infections microbiology
Candida isolation & purification
Candidiasis microbiology
Oropharynx microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-0832
- Volume :
- 177
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- Mycopathologia
- Publication Type :
- Academic Journal
- Accession number :
- 24804977
- Full Text :
- https://doi.org/10.1007/s11046-014-9753-5