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Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation.
- Source :
-
The British journal of nutrition [Br J Nutr] 2014 Jul 28; Vol. 112 (2), pp. 203-13. Date of Electronic Publication: 2014 May 07. - Publication Year :
- 2014
-
Abstract
- Previous research has shown that resveratrol can increase cerebral blood flow (CBF) in the absence of improved cognitive performance in healthy, young human subjects during the performance of cognitively demanding tasks. This lack of cognitive effects may be due to low bioavailability and, in turn, reduced bioefficacy of resveratrol in vivo. Piperine can alter polyphenol pharmacokinetics, but previous studies have not investigated whether this affects the efficacy of the target compound. Therefore, the objective of the present study was to ascertain whether co-supplementation of piperine with resveratrol affects the bioavailability and efficacy of resveratrol with regard to cognition and CBF. The present study utilised a randomised, double-blind, placebo-controlled, within-subjects design, where twenty-three adults were given placebo, trans-resveratrol (250 mg) and trans-resveratrol with 20 mg piperine on separate days at least a week apart. After a 40 min rest/absorption period, the participants performed a selection of cognitive tasks and CBF was assessed throughout the period, in the frontal cortex, using near-IR spectroscopy. The presence of resveratrol and its conjugates in the plasma was confirmed by liquid chromatography-MS analysis carried out following the administration of the same doses in a separate cohort (n 6). The results indicated that when co-supplemented, piperine and resveratrol significantly augmented CBF during task performance in comparison with placebo and resveratrol alone. Cognitive function, mood and blood pressure were not affected. The plasma concentrations of resveratrol and its metabolites were not significantly different between the treatments, which indicates that co-supplementation of piperine with resveratrol enhances the bioefficacy of resveratrol with regard to CBF effects, but not cognitive performance, and does this without altering bioavailability.
- Subjects :
- Adult
Alkaloids blood
Alkaloids therapeutic use
Benzodioxoles blood
Benzodioxoles therapeutic use
Cognition Disorders blood
Cognition Disorders metabolism
Cognition Disorders prevention & control
Cohort Studies
Cross-Over Studies
Double-Blind Method
Female
Humans
Intestinal Absorption
Male
Nootropic Agents agonists
Nootropic Agents blood
Nootropic Agents therapeutic use
Pilot Projects
Piperidines blood
Piperidines therapeutic use
Polyunsaturated Alkamides blood
Polyunsaturated Alkamides therapeutic use
Resveratrol
Spectroscopy, Near-Infrared
Stilbenes agonists
Stilbenes blood
Stilbenes therapeutic use
Task Performance and Analysis
Young Adult
Alkaloids metabolism
Benzodioxoles metabolism
Cerebrovascular Circulation
Cognition
Dietary Supplements
Frontal Lobe blood supply
Nootropic Agents metabolism
Piperidines metabolism
Polyunsaturated Alkamides metabolism
Stilbenes metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2662
- Volume :
- 112
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The British journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 24804871
- Full Text :
- https://doi.org/10.1017/S0007114514000737