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Electrochemical switching with 3D DNA tetrahedral nanostructures self-assembled at gold electrodes.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2014 Jun 11; Vol. 6 (11), pp. 8928-31. Date of Electronic Publication: 2014 May 20. - Publication Year :
- 2014
-
Abstract
- Nanomechanical switching of functional three-dimensional (3D) DNA nanostructures is crucial for nanobiotechnological applications such as nanorobotics or self-regulating sensor and actuator devices. Here, DNA tetrahedral nanostructures self-assembled onto gold electrodes were shown to undergo the electronically addressable nanoswitching due to their mechanical reconfiguration upon external chemical stimuli. That enables construction of robust surface-tethered electronic nanodevices based on 3D DNA tetrahedra. One edge of the tetrahedron contained a partially self-complementary region with a stem-loop hairpin structure, reconfigurable upon hybridization to a complementary DNA (stimulus DNA) sequence. A non-intercalative ferrocene (Fc) redox label was attached to the reconfigurable tetrahedron edge in such a way that reconfiguration of this edge changed the distance between the electrode and Fc.
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 6
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 24802004
- Full Text :
- https://doi.org/10.1021/am501823q