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31P RINEPT MRSI and VBM reveal alterations in brain aging associated with major depression.
- Source :
-
Magnetic resonance in medicine [Magn Reson Med] 2015 Apr; Vol. 73 (4), pp. 1390-400. Date of Electronic Publication: 2014 May 05. - Publication Year :
- 2015
-
Abstract
- Purpose: Phosphomono- and diesters, the major components of the choline peak in (1) H magnetic resonance spectroscopy, are associated with membrane anabolic and catabolic mechanisms. With the refocused insensitive nuclei-enhanced polarization transfer technique, these phospholipids are edited and enhanced in the (31) P MR spectrum. In depressed patients, alterations of the choline peak and cerebral volume have been found, indicating a possible relation. Thus, combining MR phosphorous spectroscopy and volumetry in depressed patients seems to be a promising approach to detect underlying pathomechanisms.<br />Methods: Depressed in-patients were either treated with antidepressive medication or with electroconvulsive therapy and compared to matched healthy controls. (31) P magnetic resonance spectroscopy imaging was conducted before and after the treatment phases. A 3D MRI dataset for volumetry was acquired in a dedicated (1) H head coil.<br />Results: Phosphocholine and phosphoethanolamine were increased in depressed patients. Though patients responded to the treatments, phospholipids were not significantly altered. An increased age-related gray matter loss in fronto-limbic regions along with an altered relation of phosphomonoesters/phosphodiesters with age were found in depressed patients.<br />Discussion: The findings of increased phosphomonoesthers and an age*group interaction for gray matter volumes need further research to define the role of phospholipids in major depression and possible associations to gray matter loss.<br /> (© 2014 Wiley Periodicals, Inc.)
- Subjects :
- Aging pathology
Algorithms
Brain pathology
Depressive Disorder, Major pathology
Female
Humans
Male
Middle Aged
Phosphorus Isotopes pharmacokinetics
Reproducibility of Results
Sensitivity and Specificity
Tissue Distribution
Aging metabolism
Brain metabolism
Depressive Disorder, Major metabolism
Magnetic Resonance Spectroscopy methods
Molecular Imaging methods
Phosphorylcholine metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1522-2594
- Volume :
- 73
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Magnetic resonance in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 24798730
- Full Text :
- https://doi.org/10.1002/mrm.25278