EBC-219: a new diterpene skeleton, crotinsulidane, from the Australian rainforest containing a bridgehead double bond.

Authors :: Maslovskaya LA
Savchenko AI
Krenske EH
Pierce CJ
Gordon VA
Reddell PW
Parsons PG
Williams CM
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2014 Jul 01; Vol. 53 (27), pp. 7006-9. Date of Electronic Publication: 2014 May 05.
Publication Year :: 2014
Abstract: EBC-219 (4), isolated from Croton insularis (Baill), was established by spectroscopic and DFT methods as the first member of a new diterpene skeletal class, uniquely defined by the presence of a bicyclo[10.2.1] bridgehead olefin. The proposed biogenetic pathway to 4 from the co-isolated natural products EBC-131 (1), EBC-180 (2) and EBC-181 (3) is highly likely. EBC-180 (2) and EBC-181 (3) showed moderate to strong cytotoxic activity against various cancer cell lines.<br /> (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Australia
Biological Products isolation & purification
Biological Products toxicity
Cell Line
Cell Survival drug effects
Diterpenes toxicity
HT29 Cells
HeLa Cells
Humans
K562 Cells
MCF-7 Cells
Magnetic Resonance Spectroscopy
Molecular Conformation
Biological Products chemistry
Diterpenes chemistry

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