Serial brain ¹⁸FDG-PET in anti-AMPA receptor limbic encephalitis.

Authors :: Spatola M
Stojanova V
Prior JO
Dalmau J
Rossetti AO
Source :: Journal of neuroimmunology [J Neuroimmunol] 2014 Jun 15; Vol. 271 (1-2), pp. 53-5. Date of Electronic Publication: 2014 Apr 16.
Publication Year :: 2014
Abstract: Immunotherapy-responsive autoimmune CNS syndromes linked to antibodies targeting surface neuronal antigens lack reliable biomarkers of disease activity. We report serial cerebral (18)FDG PET studies in a woman with AMPA receptor (AMPA-R) autoimmune limbic encephalitis. During her follow-up, despite an aggressive immunotherapy, she displayed a persistent, predominantly left hippocampal FDG hypermetabolism, in the absence of CNS inflammatory signs. Brain metabolism abnormalities regressed after increasing antiepileptic treatment, correlating with a moderate clinical improvement. Brain (18)F-FDG PET could thus represent a useful complementary tool to orient the clinical follow-up.<br /> (Copyright © 2014 Elsevier B.V. All rights reserved.)