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Relationship between changes in alveolar surfactant levels and lung defence mechanisms.
- Source :
-
Respiration; international review of thoracic diseases [Respiration] 1989; Vol. 55 Suppl 1, pp. 53-9. - Publication Year :
- 1989
-
Abstract
- Pulmonary surfactant, besides its mechanical properties, is thought to be involved in lung defence mechanisms. We previously described that: (1) in healthy animals, surfactant synthesis stimulation with ambroxol was accompanied by alveolar macrophage activation and a shift of the alveolar elastase/antielastase balance towards increased antielastase activity, and (2) in bleomycin-treated rats alveolar phospholipidosis was obvious 14 days after drug administration, ambroxol protection reduced the phospholipid peak and the morphological apperance of lung fibrosis at the 14th day of the experiment. The present study found that: (1) in healthy rats, the ambroxol-induced increase of alveolar antielastase activity did not appear due to reactivation of alpha 1-antitrypsin normally oxidized in the alveolar milieu; (2) in bleomycin-induced pulmonary fibrosis, ambroxol protection reduced total long collagen content at day 28, and (3) in paraquat-induced pulmonary fibrosis, alveolar phospholipids were markedly reduced throughout the 21 days of the experiment. On increasing the dose of paraquat, ambroxol protection significantly reduced the animals' death rate.
- Subjects :
- Ambroxol pharmacology
Animals
Bleomycin
Bronchoalveolar Lavage Fluid analysis
Collagen analysis
Glutathione analysis
Macrophage Activation drug effects
Methionine Sulfoxide Reductases
Oxidoreductases
Paraquat pharmacokinetics
Pulmonary Alveoli immunology
Pulmonary Fibrosis chemically induced
Rats
Lung immunology
Pulmonary Surfactants physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0025-7931
- Volume :
- 55 Suppl 1
- Database :
- MEDLINE
- Journal :
- Respiration; international review of thoracic diseases
- Publication Type :
- Academic Journal
- Accession number :
- 2479066
- Full Text :
- https://doi.org/10.1159/000195752