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Long-term 24-hour intraocular pressure control with travoprost monotherapy in patients with primary open-angle glaucoma.
- Source :
-
Journal of glaucoma [J Glaucoma] 2014 Oct-Nov; Vol. 23 (8), pp. 535-40. - Publication Year :
- 2014
-
Abstract
- Purpose: The aim of the study was to evaluate the long-term 24-hour intraocular pressure (IOP) efficacy of travoprost monotherapy in primary open-angle glaucoma patients.<br />Patients and Methods: A total of 36 previously untreated primary open-angle glaucoma patients were enrolled in this 5-year study. Patients underwent an untreated 24-hour IOP evaluation. Subsequently all patients were assigned to topical therapy with travoprost 0.004% eye-drops preserved with benzalkonium chloride (Travatan, Alcon Laboratories Inc., Fort Worth, TX) administered once in the evening (8:00 PM) in both eyes. All patients were then scheduled for a 24-hour IOP assessment approximately 12 months after the baseline visit. This schedule of follow-up was maintained for the whole duration of the trial. The predetermined range of target IOP reduction selected in this cohort of patients ranged between 20% and 30%.<br />Results: A total of 34 patients completed all phases of the investigation. The mean survival time was 57.3±2.0 months and the cumulative survival rate was 0.82±0.6 at 60 months. Travoprost reduced the mean 24-hour IOP from 23.4±1.7 mm Hg at baseline to 16.8±2.4 mm Hg (28.4%), 16.8±2.5 mm Hg (28.1%), 16.8±2.4 mm Hg (28.5%), 16.7±2.5 mm Hg (28.6%), and 16.9±2.4 mm Hg (27.8%), respectively at the end of the first, second, third, fourth, and fifth year follow-up. No drug-related serious adverse events were registered during the study.<br />Conclusions: The present study demonstrated the long-term 24-hour efficacy of travoprost for the treatment of primary open-angle glaucoma.
- Subjects :
- Aged
Aged, 80 and over
Cloprostenol administration & dosage
Female
Glaucoma, Open-Angle physiopathology
Humans
Male
Middle Aged
Ophthalmic Solutions
Prospective Studies
Travoprost
Antihypertensive Agents administration & dosage
Cloprostenol analogs & derivatives
Glaucoma, Open-Angle drug therapy
Intraocular Pressure drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1536-481X
- Volume :
- 23
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of glaucoma
- Publication Type :
- Academic Journal
- Accession number :
- 24786103
- Full Text :
- https://doi.org/10.1097/IJG.0000000000000073