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Safety of onabotulinum toxin a injection to the central upper eyelid and eyebrow regions.
- Source :
-
Ophthalmic plastic and reconstructive surgery [Ophthalmic Plast Reconstr Surg] 2014 Sep-Oct; Vol. 30 (5), pp. 377-80. - Publication Year :
- 2014
-
Abstract
- Purpose: To evaluate the safety of onabotulinum toxin A injected into the central upper eyelid and eyebrow regions.<br />Methods: The authors retrospectively reviewed the charts of all patients undergoing onabotulinum toxin A injection to the central upper eyelid and eyebrow between February, 2012, and November, 2012. Age, gender, indication, injection sites, number of central units, total number of units, and occurrence of adverse events were all recorded.<br />Results: A total of 300 procedures on 88 patients were performed, in whom the central upper eyelid and/or central eyebrow was injected with onabotulinum toxin A. There were 68 female and 20 male patients. Average age was 68.7±13.3 years (range, 42-92 years). Indications for central eyelid/eyebrow treatment included blepharospasm (34 patients, 176 procedures), hemifacial spasm (21 patients, 40 procedures), facial nerve disorders (2 patients, 9 procedures), and facial rhytides/eyebrow ptosis (31 patients, 75 procedures). The amount of neurotoxin injected into the central eyelid and eyebrow ranged from 2 to 12.5 units per encounter. Complications included diplopia (4% of total encounters), lagophthalmos (1% of total encounters), blepharoptosis (1% of total encounters), and blurry vision (1% of total encounters). Minor local effects, including bruising, bleeding, pain, and mild swelling, were recorded in 3.3% of total encounters.<br />Conclusions: Placement of onabotulinum toxin A into the central upper eyelid and eyebrow is associated with a low rate of blepharoptosis. Central eyelid and eyebrow neurotoxin injection can be safely added to the regimen when treatment calls for chemodenervation of the central orbicularis oculi.
- Subjects :
- Acetylcholine Release Inhibitors adverse effects
Adult
Aged
Aged, 80 and over
Blepharoptosis drug therapy
Blepharospasm drug therapy
Botulinum Toxins, Type A adverse effects
Eyelid Diseases
Facial Nerve Diseases drug therapy
Female
Hemifacial Spasm drug therapy
Humans
Injections, Intraocular
Male
Middle Aged
Retrospective Studies
Acetylcholine Release Inhibitors administration & dosage
Botulinum Toxins, Type A administration & dosage
Eyebrows drug effects
Eyelids drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1537-2677
- Volume :
- 30
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Ophthalmic plastic and reconstructive surgery
- Publication Type :
- Academic Journal
- Accession number :
- 24777259
- Full Text :
- https://doi.org/10.1097/IOP.0000000000000109