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Assessment of cross-reactive host-pathogen antibodies in patients with different stages of chronic Chagas disease.
- Source :
-
Revista espanola de cardiologia (English ed.) [Rev Esp Cardiol (Engl Ed)] 2013 Oct; Vol. 66 (10), pp. 791-6. Date of Electronic Publication: 2013 Aug 22. - Publication Year :
- 2013
-
Abstract
- Introduction and Objectives: Trypanosoma cruzi infection has been shown to induce humoral autoimmune responses against host antigens tissues. Particularly, antibodies cross-reacting with myocardial antigens may play a role in the development of the severe forms of chronic Chagas disease. The aim of this study was to determine the association between clinical stage of the disease and the presence of autoantibodies in patients with chronic Chagasic disease.<br />Methods: We performed a cross-sectional study in T. cruzi-seropositive patients divided into 3 groups according to the classic classification of chronic Chagas heart of Storino et al. All participants underwent complete clinical examination and their sera were used to measure autoantibody levels.<br />Results: All patients had detectable levels of anti-p2β and anti-B13 autoantibodies but none had anti-Na-K-ATPase antibodies. No association was observed between electrocardiographic conduction disturbances and autoantibody levels. Patients with chronic Chagas disease stage III had the highest levels of anti-B13 antibodies and a high risk of mortality score, showing a clear association between disease stage and this score.<br />Conclusions: Anti-B13 antibodies were significantly higher in chronic Chagas disease stage III patients, suggesting that these antibodies may be involved in disease progression and that they might be a useful marker of poor prognosis in terms of heart compromise. Our results also reveal an important correlation between the level of anti-B13 autoantibodies and symptomatic heart failure and/or dilated cardiomyopathy.<br /> (Copyright © 2013 Sociedad Española de Cardiología. Published by Elsevier Espana. All rights reserved.)
- Subjects :
- Adult
Aged
Antibodies, Protozoan immunology
Autoantibodies analysis
Chagas Cardiomyopathy diagnostic imaging
Chagas Cardiomyopathy physiopathology
Chronic Disease
Cross-Sectional Studies
Disease Progression
Echocardiography, Doppler methods
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Heart Failure etiology
Heart Failure mortality
Heart Failure physiopathology
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Reference Values
Risk Assessment
Severity of Illness Index
Survival Analysis
Autoantibodies immunology
Chagas Cardiomyopathy immunology
Chagas Cardiomyopathy mortality
Host-Pathogen Interactions immunology
Trypanosoma cruzi immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1885-5857
- Volume :
- 66
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Revista espanola de cardiologia (English ed.)
- Publication Type :
- Academic Journal
- Accession number :
- 24773859
- Full Text :
- https://doi.org/10.1016/j.rec.2013.05.028