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Delivery of BMP-2 by two clinically available apatite materials: in vitro and in vivo comparison.
- Source :
-
Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2015 Feb; Vol. 103 (2), pp. 628-38. Date of Electronic Publication: 2014 May 09. - Publication Year :
- 2015
-
Abstract
- Bone morphogenetic proteins (BMPs) are deposited in bone and responsible for osteoinduction. The interplay between delivery system and BMP, resulting in a characteristic release profile, is crucial for clinical success. We here report on two apatite based commercially available granules which could potentially be used in a combination product with recombinant human BMP-2 (rhBMP-2). Regardless of their similar chemistry, their interaction with rhBMP-2 differs. Deproteinized bovine bone matrix (DBBM), a clinically well-established bone substitute, has a high affinity to rhBMP-2 and releases only 50% of the growth factor during the first 2 weeks in vitro. Activity of the physio-adsorbed rhBMP-2 is indicated by an enhanced bone augmentation in vivo. In contrast, all rhBMP-2 delivered in combination with synthetic hydroxyapatite/β-tricalcium phosphate (HA/TCP) granules is released during the first 24 h. For both HA/TCP and DBBM, the released rhBMP-2 is active in vitro. Our results suggest that the different release behavior from these two apatite granules is due to the 1000-fold higher specific surface area of DBBM compared to HA/TCP.<br /> (© 2014 Wiley Periodicals, Inc.)
- Subjects :
- Animals
Cattle
Delayed-Action Preparations chemistry
Delayed-Action Preparations pharmacokinetics
Delayed-Action Preparations pharmacology
Humans
Rabbits
Bone Morphogenetic Protein 2 chemistry
Bone Morphogenetic Protein 2 pharmacokinetics
Bone Morphogenetic Protein 2 pharmacology
Bone Substitutes chemistry
Bone Substitutes pharmacology
Calcium Phosphates chemistry
Calcium Phosphates pharmacology
Durapatite chemistry
Durapatite pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1552-4965
- Volume :
- 103
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of biomedical materials research. Part A
- Publication Type :
- Academic Journal
- Accession number :
- 24771467
- Full Text :
- https://doi.org/10.1002/jbm.a.35211