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The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods.
- Source :
-
European child & adolescent psychiatry [Eur Child Adolesc Psychiatry] 2015 Feb; Vol. 24 (2), pp. 141-51. Date of Electronic Publication: 2014 Apr 26. - Publication Year :
- 2015
-
Abstract
- Tourette syndrome (TS) is a neuropsychiatric disorder characterized by recurrent motor and vocal tics, often accompanied by obsessive-compulsive disorder and/or attention-deficit/hyperactivity disorder. While the evidence for a genetic contribution is strong, its exact nature has yet to be clarified fully. There is now mounting evidence that the genetic risks for TS include both common and rare variants and may involve complex multigenic inheritance or, in rare cases, a single major gene. Based on recent progress in many other common disorders with apparently similar genetic architectures, it is clear that large patient cohorts and open-access repositories will be essential to further advance the field. To that end, the large multicenter Tourette International Collaborative Genetics (TIC Genetics) study was established. The goal of the TIC Genetics study is to undertake a comprehensive gene discovery effort, focusing both on familial genetic variants with large effects within multiply affected pedigrees and on de novo mutations ascertained through the analysis of apparently simplex parent-child trios with non-familial tics. The clinical data and biomaterials (DNA, transformed cell lines, RNA) are part of a sharing repository located within the National Institute for Mental Health Center for Collaborative Genomics Research on Mental Disorders, USA, and will be made available to the broad scientific community. This resource will ultimately facilitate better understanding of the pathophysiology of TS and related disorders and the development of novel therapies. Here, we describe the objectives and methods of the TIC Genetics study as a reference for future studies from our group and to facilitate collaboration between genetics consortia in the field of TS.
- Subjects :
- Attention Deficit Disorder with Hyperactivity psychology
Child
Cooperative Behavior
Female
Gene-Environment Interaction
Genetic Linkage
Genetic Predisposition to Disease
Genomics
Humans
Obsessive-Compulsive Disorder psychology
Pedigree
Tic Disorders psychology
Tics psychology
Tourette Syndrome psychology
Attention Deficit Disorder with Hyperactivity complications
Obsessive-Compulsive Disorder complications
Tic Disorders complications
Tics complications
Tourette Syndrome genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1435-165X
- Volume :
- 24
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European child & adolescent psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 24771252
- Full Text :
- https://doi.org/10.1007/s00787-014-0543-x